American Cruise Line Cruise Deals
American Cruise Line cruise deals open the door to explore American's beautiful and iconic Rivers. American Cruise Line offers cruises on the Mississippi River, the Hudson River and the Columbia and Snake Rivers. Immerse yourself in the southern history and culture of the Mississippi from St. Paul to New Orleans. The stunning views and historical sites of the Hudson River are highlighted on a Hudson River Cruise. The Columbia & Snake river lets you explore the Pacific Northwest. Book now and get the best deals on your next American Cruise Line cruise vacation.
Featured American Cruise Line Deals
Best American Cruise Line Deals by Destination
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American West
Clarkston to Portland/Oregon
May 10, 2024 - Jul 20, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Pride
Portland/Oregon to Clarkston
May 12, 2024 - Nov 9, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Pride
Clarkston to Portland/Oregon
May 19, 2024 - Nov 2, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Harmony
Clarkston to Portland/Oregon
May 16, 2024 - Dec 29, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Symphony
New Orleans to Memphis
Oct 18, 2024 - Dec 24, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Liberty
Charleston/South Carolina to Amelia Island
Nov 23, 2024 - May 16, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Independence
Baltimore to Amelia Island
Nov 6, 2024 - Nov 4, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Serenade
Saint Louis to Saint Paul
Jul 16, 2024 - Aug 8, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
American Melody
Saint Louis to Saint Paul
Jul 26, 2024 - Oct 10, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
All offers are based on select sailings and categories and are subject to availability at time of booking. All rates are per person based on double occupancy.