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American Cruise Line Cruise Deals
American Cruise Line cruise deals open the door to explore American's beautiful and iconic Rivers. American Cruise Line offers cruises on the Mississippi River, the Hudson River and the Columbia and Snake Rivers. Immerse yourself in the southern history and culture of the Mississippi from St. Paul to New Orleans. The stunning views and historical sites of the Hudson River are highlighted on a Hudson River Cruise. The Columbia & Snake river lets you explore the Pacific Northwest. Book now and get the best deals on your next American Cruise Line cruise vacation.
Featured American Cruise Line Deals
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Free Airfare & up to $1,000 Savings on select 2024 Fall Lower Mississippi River cruise
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Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
- Complimentary cocktail hour held each evening
- Afternoon tea service in the Sky Lounge
- Breakfast room service
Best American Cruise Line Deals by Destination
8 Day US & Canada River Cruises
American Pride
Portland/Oregon to Clarkston
Apr 27, 2025 - Nov 9, 2026
American Pride
Portland/Oregon to Clarkston
Apr 27, 2025 - Nov 9, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,485
COLUMBIA & SNAKE RIVER CRUISE
8 Day US & Canada River Cruises
American Pride
Clarkston to Portland/Oregon
May 4, 2025 - Nov 2, 2026
American Pride
Clarkston to Portland/Oregon
May 4, 2025 - Nov 2, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,787
COLUMBIA & SNAKE RIVER CRUISE
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,876
8 Day US & Canada River Cruises
American West
Clarkston to Portland/Oregon
May 11, 2025 - Jul 20, 2026
American West
Clarkston to Portland/Oregon
May 11, 2025 - Jul 20, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,876
COLUMBIA & SNAKE RIVER CRUISE
8 Day US & Canada River Cruises
American Song
Clarkston to Portland/Oregon
Apr 8, 2025 - Nov 4, 2026
American Song
Clarkston to Portland/Oregon
Apr 8, 2025 - Nov 4, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,228
COLUMBIA & SNAKE RIVER CRUISE
8 Day US & Canada River Cruises
American Harmony
Clarkston to Portland/Oregon
Apr 4, 2025 - Oct 17, 2026
American Harmony
Clarkston to Portland/Oregon
Apr 4, 2025 - Oct 17, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $6,054
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Call
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Call
Fall Foliage Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,000
Fall Foliage Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,356
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,356
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,356
Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $3,619
Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,253
Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,866
Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,084
Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,223
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,782
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,911
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $6,287
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $6,643
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,000
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,262
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $7,703
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,564
7 Day US & Canada Eastern
American Independence
Charleston/South Carolina to Amelia Island
Mar 15 - Apr 12, 2025
American Independence
Charleston/South Carolina to Amelia Island
Mar 15 - Apr 12, 2025
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,485
7 Day US & Canada Eastern
American Independence
Amelia Island to Charleston/South Carolina
Mar 22 - Apr 19, 2025
American Independence
Amelia Island to Charleston/South Carolina
Mar 22 - Apr 19, 2025
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,485
7 Day US & Canada Eastern
American Eagle
Amelia Island to Charleston/South Carolina
Dec 22, 2024 - Apr 30, 2026
American Eagle
Amelia Island to Charleston/South Carolina
Dec 22, 2024 - Apr 30, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,960
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,752
7 Day US & Canada Eastern
American Liberty
Charleston/South Carolina to Amelia Island
Dec 21, 2024 - May 16, 2026
American Liberty
Charleston/South Carolina to Amelia Island
Dec 21, 2024 - May 16, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $6,465
14 Day US & Canada Eastern
American Eagle
Amelia Island to Washington, D.C.
May 19, 2025 & May 13, 2026
American Eagle
Amelia Island to Washington, D.C.
May 19, 2025 & May 13, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,480
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,841
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $6,440
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $8,876
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,702
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,514
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,514
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $13,959
Upper Mississippi River Cruise
7 Day US & Canada River Cruises
American Melody
Saint Louis to Saint Paul
Jul 18, 2025 - Oct 10, 2026
American Melody
Saint Louis to Saint Paul
Jul 18, 2025 - Oct 10, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,490
Upper Mississippi River Cruise
7 Day US & Canada River Cruises
American Serenade
Saint Louis to Saint Paul
Jul 11, 2025 - Aug 8, 2026
American Serenade
Saint Louis to Saint Paul
Jul 11, 2025 - Aug 8, 2026
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $5,490
Upper Mississippi River Cruise
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $10,638
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,233
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,579
- Included Amenities: FREE Wi-Fi & Complimentary cocktail hour each evening and Much More!
Fr $4,728
All offers are based on select sailings and categories and are subject to availability at time of booking. All rates are per person based on double occupancy.
